The pastorate of Rev. Nolan continued. Bolton Hill saw some famous people take up (at least temporary) residence, such as Zelda and F. Scott Fitzgerald, Gertrude Stein, and the famous Cone sisters, Claribel and Etta. Although in the 1920s Bolton Hill was still a grand place to live, the neighborhood was changing; cars and urban expansion were leaving their mark.

A new school was built in 1925, even in the midst of the urban renewal that limited parish boundaries even further. Then, the devastating stock market crash of 1929 further eroded parish income. That same year, the School Sisters of Notre Dame formally assumed the administration of the school.